Zenescope was founded in 2005 by two natives of Philadelphia, Pennsylvania, Joe Brusha and Ralph Tedesco. Although an independent company it has made a name for itself, primarily through its flagship franchise, Grimm Fairy Tales. The titles are known primarily for their covers, which often depict women in revealing poses. However, the titles themselves have very little exploitation of female characters for their bodies and in fact generally contain very strong female characters. The foremost among these are Sela and Belinda, the two characters that form the backbone of the main series, and thus essentially the entire Grimm Fairy Tales multiverse.

Zenescope also has had a business arrangement with New Line Cinema, having produced two miniseries based on films which they hold the rights to - Se7en and Final Destination.