Raffaele Ienco is best known for writing and drawing Devoid of Life, the graphic novel from Image Comics. The story involves a hidden planet that is discovered in our solar system by astronomers who are killed by xenophobic aliens bent on keeping their world a secret.

More recently, in May of 2012 Ienco released a new title in which he also writes and does pencil work. The book is entitled Epic Kill and chronicles the life of an eighteen year old super assassin named Song. Her primary objective being to find and eliminate the man responsible for the death of her parents.

Epic Kill was originally meant to be a five issue limited series but with it's success in sales over the summer of 2012 the series has gone ongoing with a continuation from the Climax of the original story arc.