Spider-Man's adventure involves the first appearance of Cloak & Dagger.

After witnessing the murder of a drug-dealer by two superpowered beings called "Cloak" and "Dagger," Spider-Man's investigations led him to Ellis Island, where the two vigilantes had rounded up a group of criminals who were part of an experiment on drug-addiction involving a bunch of dead kids. Spider-Man managed to stop Cloak and Dagger in time before any more killings were done, but through Cloak's actions, the criminals ended up falling to their deaths from a window.

Before Spider-Man could do anything else, both vigilantes disappeared into the shadows, leaving a very disturbed web-slinger.