Prof is the Amalgam version of DC's Prof Haley and Marvel's Mister Fantastic. 
 
Reed is a genius and uses his knowledge for the benefit of human kind. While testing an experimental rocket to see if it could make manned spaceflight safe from cosmic mutations, he was betrayed by his partner Victor Von Doom. The spacecraft crashed to Earth, but all survived. From this day forth they were known as the Challengers of the Fantastic.  
 
In battle with Galactiac, Reed used Doctor Octavius' anima-tentacles. He has also sworn to find a way to turn Rocky back into the Four-Armed Thing.